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. 1976 Jul 30;193(4251):403-5.
doi: 10.1126/science.819993.

Thyrotropin releasing hormone: development of inactivation system during maturation of the rat

J T Neary, J D Kieffer, P Federico, H Mover, F Maloof, M Soodak

Thyrotropin releasing hormone: development of inactivation system during maturation of the rat

J T Neary et al. Science. .

Abstract

Whereas thyrotropin releasing hormone is rapidly and extensively degraded by plasma of adult rats, no appreciable loss of biological or immunological activity is caused by plasma from rats 4 or 16 days old. The plasma of neonatal rats does not appear to contain an inhibitor of thyrotropin releasing hormone peptidase or a peptidase with altered substrate affinity. The development of an active peptidase in rat plasma suggests a physiological role for inactivation of thyrotropin releasing hormone.

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