[Influence of the conservative cholelitholytic therapy using chenodesoxycholic acid (CDC) on cholesterol and triglycerides in the blood of patients with gall stones]

Abstract

In 11 patients with radiolucent gallstones treated for 3-18 months with chenodeoxycholic acid (CDC) serum cholesterol and triglyceride levels were measured. No significant changes of serum cholesterol and triglycerides could be observed during the course of longterm treatment with CDC. After 3 and 6 months a not significant decrease of serum triglycerides (20.8% and 26.4% respectively) compared to pretreatment values was observed. Since hypercholesterolemia had been suggested to occur as a hazardous side-effect of CDC-treatment the results in accord with cholesterol pool size measurements suggest that long-term treatment with CDC does not result in hypercholesterolemia and an increased cholesterol pool-size.