Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1994 Jun;12(6):1121-5.
doi: 10.1200/JCO.1994.12.6.1121.

Randomized placebo-controlled evaluation of hydrazine sulfate in patients with advanced colorectal cancer

C L Loprinzi  1 , S A Kuross, J R O'Fallon, D H Gesme Jr, J B Gerstner, R M Rospond, C D Cobau, R M Goldberg
Affiliations
Clinical Trial

Randomized placebo-controlled evaluation of hydrazine sulfate in patients with advanced colorectal cancer

C L Loprinzi et al. J Clin Oncol. 1994 Jun.

Abstract

Purpose: Hydrazine sulfate is a controversial agent that was originally studied in cancer patients approximately 20 years ago. Based on a series of recent trials that suggested that this drug might have utility in cancer patients, we conducted this study.

Patients and methods: Patients with metastatic colorectal cancer were randomized to receive hydrazine sulfate or placebo in a double-blinded manner. Protocol patients did not concurrently receive any other systemic antineoplastic treatment.

Results: There were 127 assessable patients entered onto this clinical trial. Data from the study showed trends both for poorer survival and for poorer quality of life (QL) in the hydrazine group. There were no significant differences in the two study arms with regard to anorexia or weight loss.

Conclusion: This trial failed to demonstrate any benefit for hydrazine sulfate.

PubMed Disclaimer

Comment in

Publication types

LinkOut - more resources