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. 1994 Jun 16;369(6481):533-8.
doi: 10.1038/369533a0.

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

F J de Sauvage  1 , P E Hass, S D Spencer, B E Malloy, A L Gurney, S A Spencer, W C Darbonne, W J Henzel, S C Wong, W J Kuang, et al.
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Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

F J de Sauvage et al. Nature. .

Abstract

Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis.

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Comment in

  • Blood. Thrombopoietin--at last.
    Metcalf D. Metcalf D. Nature. 1994 Jun 16;369(6481):519-20. doi: 10.1038/369519a0. Nature. 1994. PMID: 8202150 No abstract available.

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