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. 1994 Jun 7;91(12):5291-5.
doi: 10.1073/pnas.91.12.5291.

A cell cycle-regulated inhibitor of cyclin-dependent kinases

L Hengst  1 , V Dulic, J M Slingerland, E Lees, S I Reed
Affiliations

A cell cycle-regulated inhibitor of cyclin-dependent kinases

L Hengst et al. Proc Natl Acad Sci U S A. .

Abstract

Cyclin-dependent kinases (Cdks) previously have been shown to drive the major cell cycle transitions in eukaryotic organisms ranging from yeast to humans. We report here the identification of a 28-kDa protein, p28Ick (inhibitor of cyclin-dependent kinase), that binds to and inhibits the kinase activity of preformed Cdk/cyclin complexes from human cells. p28 inhibitory activity fluctuates during the cell cycle with maximal levels in G1 and accumulates in G1- and G0-arrested cells. These results suggest that control of the G1/S transition may be influenced by a family of Cdk inhibitors that include p28Ick and the recently described inhibitors p21Cip1/Waf1/Cap20 and p16Ink4.

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