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Comparative Study
. 1978 Nov 11;2(8098):1023-4.
doi: 10.1016/s0140-6736(78)92341-3.

Selective inactivation of vitamin B12 in rats by nitrous oxide

R Deacon, M Lumb, J Perry, I Chanarin, B Minty, M J Halsey, J F Nunn
Comparative Study

Selective inactivation of vitamin B12 in rats by nitrous oxide

R Deacon et al. Lancet. .

Abstract

Exposure of rats to nitrous oxide rapidly inactivated the cytosol enzyme, methionine synthetase, but the mitochondrial enzyme, methylmalonyl CoA mutase, seemed to be unaffected, although both enzymes require vitamin B12.

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