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. 1994 Mar;38(3):628-31.
doi: 10.1128/AAC.38.3.628.

Impact of dosing schedule upon suppression of a retrovirus in a murine model of AIDS encephalopathy

J A Bilello  1 , J L Eiseman, H C Standiford, G L Drusano
Affiliations

Impact of dosing schedule upon suppression of a retrovirus in a murine model of AIDS encephalopathy

J A Bilello et al. Antimicrob Agents Chemother. 1994 Mar.

Abstract

We studied the impact of zidovudine (AZT) in Cas-Br-M murine leukemia virus-infected NFS-N mice after administration by once-daily bolus or continuous infusion. While higher peak concentrations of AZT were achieved by once-daily dosing, continuous AZT infusion at 25 micrograms/h maintained levels > 1 microM in plasma and > 0.2 microM in the brain. Continuous infusion provided significantly better viral inhibition, even though total doses were only one-third that of the once-daily therapy group.

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