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. 1976 Jul;14(1):318-9.
doi: 10.1128/iai.14.1.318-319.1976.

Modified polyriboinosinic-polyribocytidylic acid, an immunological adjuvant

W E Houston, C L Crabbs, E L Stephen, H B Levy

Modified polyriboinosinic-polyribocytidylic acid, an immunological adjuvant

W E Houston et al. Infect Immun. 1976 Jul.

Abstract

Stabilization of polyriboinosinic-polyribocytidylic acid against enzymatic hydrolysis by addition of poly-1-lysine and carboxymethylcellulose (PICLC) resulted in a compound with marked adjuvanticity. The primary antibody response of rhesus monkeys to formalin-inactivated Venezuelan equine encephalomyelitis virus vaccine was significantly potentiated if the vaccine was combined with PICLC prior to vaccination. The antibody response was maintained at a significantly higher level than controls for 2.5 months postvaccination and paralleled immunological responses reported for live, attenuated (TC-83) vaccine.

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References

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