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. 1994 Jun;44(6):1064-8.
doi: 10.1212/wnl.44.6.1064.

Initial and follow-up brain MRI findings and correlation with the clinical course in Wilson's disease

J K Roh  1 , T G Lee, B A Wie, S B Lee, S H Park, K H Chang
Affiliations

Initial and follow-up brain MRI findings and correlation with the clinical course in Wilson's disease

J K Roh et al. Neurology. 1994 Jun.

Abstract

We performed pretreatment brain MRIs in 25 patients with neurologically symptomatic Wilson's disease (WD) and clinical and MRI follow-up in 16 of them. All 25 pretreatment MRIs revealed abnormalities, with abnormal high-signal intensity (HSI) in bilateral thalami being the most common (92%). HSI lesions in the brainstem (84%) and the basal ganglia (72%) were also common. Brain atrophy was present in 88% of the 25 patients. In the follow-up period of 5 to 24 months, during which the patients were treated with D-penicillamine, both HSI lesions and neurologic symptoms improved in 88% of the 16 patients, but the brain atrophy did not change.

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