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Case Reports
. 1993 Oct;86(10):1170-2.
doi: 10.1097/00007611-199310000-00021.

Platelet dysfunction associated with clozapine therapy

R Durst  1 , A Dorevitch, Y Fraenkel
Affiliations
Case Reports

Platelet dysfunction associated with clozapine therapy

R Durst et al. South Med J. 1993 Oct.

Abstract

Clozapine, an atypical antipsychotic agent used in cases of treatment-resistant schizophrenia, is known for its relative absence of extrapyramidal side effects and its potential hazardous effect on white blood cell function. We have described a case of clozapine-associated epistaxis and reduction of the platelet count. Discontinuance of clozapine therapy resulted in cessation of epistaxis followed by normalization of the platelet count. We suggest routine monitoring of platelet count and function in patients treated with clozapine.

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