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Case Reports
. 1993;423(2):145-50.
doi: 10.1007/BF01606589.

Detection of Epstein-Barr virus in a case of undifferentiated nasopharyngeal carcinoma by in situ hybridization with digoxigenin-labelled PCR-generated probes

P Delvenne  1 , B Kaschten, J M Deneufbourg, L Demanez, A Stevenaert, M Reznik, J Boniver
Affiliations
Free article
Case Reports

Detection of Epstein-Barr virus in a case of undifferentiated nasopharyngeal carcinoma by in situ hybridization with digoxigenin-labelled PCR-generated probes

P Delvenne et al. Virchows Arch A Pathol Anat Histopathol. 1993.
Free article

Abstract

A case of nasopharyngeal carcinoma is presented. Epstein-Barr viral genome was identified in the neoplastic cells by in situ hybridization with digoxigenin-labelled polymerase chain reaction-generated probes. We report the development of this technique in paraffin-embedded sections and propose that such identification may prove valuable for the diagnosis of this tumour in routine material.

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