[A comparison of the therapeutic effect between preoperative radiotherapy plus operation and operation alone for laryngocarcinoma. A prospective study of 260 cases]

Abstract

A prospective study on the therapeutic effect of either preoperative radiotherapy and operation (101 cases) or operation alone (159 cases) by random grouping for a total of 260 patients with laryngocarcinoma were conducted. By analysing the survival curve and time schedule test, we compared the population survival rate, clinical typing, T classification, staging, pathological grading, operative method and infection rate between the two groups. The result shows that there is no significant difference between survival curves. It is indicated that the preoperative radiotherapy can increase neither the five-year survival rate nor the postoperative infection rate evidently, but it may increase the survival rates of those with poorly differentiated squamous carcinoma (grade III or IV), those in advanced stage carcinoma (T3 or T4 stage IV) or those who will undergo extensive laryngectomy. The three-year and five-year survival rates were 75.4% and 67.5% respectively; for the glottic type the rates were 78.4% and 71.0%; 73.7% and 64.5% for the supraglottic type; 76.1% and 72.3% for the partial laryngectomy; and 71.4% and 53.9% for the total laryngectomy.