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. 1993;106(2):85-90.
doi: 10.1007/BF01225046.

The application of mitochondrial DNA typing to the study of white Caucasian genetic identification

R Piercy  1 , K M Sullivan, N Benson, P Gill
Affiliations

The application of mitochondrial DNA typing to the study of white Caucasian genetic identification

R Piercy et al. Int J Legal Med. 1993.

Abstract

Mitochondrial DNA (mtDNA) from 100 unrelated British White Caucasians was extracted, amplified and directly sequenced. Sequences of approximately 800 nucleotides were obtained from 2 hypervariable segments within the non-coding region of the mitochondrial genome. A total of 91 different sequences were observed with an average nucleotide diversity of 1.1%. The most diverse pair of sequences differed at 3.6% of their nucleotide (nt) sites. Comparison to a consensus reference sequence showed that each region was polymorphic to a similar extent. Different methods of genetic analysis were used to examine the variation in each region, including pairwise comparisons, which demonstrated that although the data did not fit a Poisson distribution, the fit was closer to a Negative Binomial distribution.

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