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. 1976 Sep;43(3):550-6.
doi: 10.1210/jcem-43-3-550.

Thyroid-stimulating immunoglobulins and the control of thyroid function

R Clague, E D Mukhtar, G A Pyle, J Nutt, F Clark, M Scott, D Evered, B R Smith, R Hall

Thyroid-stimulating immunoglobulins and the control of thyroid function

R Clague et al. J Clin Endocrinol Metab. 1976 Sep.

Abstract

Triiodothyronine (T3) suppression and thyrotropin-releasing hormone (TRH) tests were used to study thyroid function in 50 patients with thyroid disease. The results of the thyroid function tests were compared with the levels of serum thyroid-stimulating immunoglobulins (TSI) measured by a radio-receptor assay. In euthyroid and hyperthyroid patients, the presence of TSI corresponded with the absence of TSH control of thyroid function. However, in two hypothyroid patients with serum TSI levels readily detectable in the receptor assay, T3 suppression and TRH tests indicated that thyroid function was under TSH control.

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