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. 1993 Sep 3;621(1):111-5.
doi: 10.1016/0006-8993(93)90304-6.

Spinal cord motoneurons express p75NGFR and p145trkB mRNA in amyotrophic lateral sclerosis

J L Seeburger  1 , S Tarras, H Natter, J E Springer
Affiliations

Spinal cord motoneurons express p75NGFR and p145trkB mRNA in amyotrophic lateral sclerosis

J L Seeburger et al. Brain Res. .

Abstract

In the present study, in situ hybridization was used to examine the expression of nerve growth factor (NGF) receptor (p75NGFR), trk (p140trk) and trkB (p145trkB) mRNA in spinal cord sections from patients with amyotrophic lateral sclerosis (ALS). We report that the expression of p75NGFR and p145trkB mRNA is elevated in alpha motoneurons in ALS sections. However, p140trk mRNA was not expressed in either ALS or control sections.

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