Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Nov 15;72(10):3029-35.
doi: 10.1002/1097-0142(19931115)72:10<3029::aid-cncr2820721027>3.0.co;2-6.

Metallothionein in testicular germ cell tumors and drug resistance. Clinical correlation

J L Chin  1 , D Banerjee, S A Kadhim, T E Kontozoglou, P J Chauvin, M G Cherian
Affiliations

Metallothionein in testicular germ cell tumors and drug resistance. Clinical correlation

J L Chin et al. Cancer. .

Abstract

Background: Metallothioneins (MT) are endogenous metalloproteins involved in the homeostasis of essential metals and detoxification of toxic metals. Some recent experimental studies suggested tumor resistance to cisdiamminedichloroplatin may be associated with overexpression of MT in the tumor.

Methods: The presence of MT in 33 primary testicular germ cell tumor specimens was assessed immunohistochemically using a rabbit polyclonal rat liver MT antibody that cross-reacted with human MT. The data were correlated with the patients' clinical course.

Results: Seminomas stained weakly or not at all for MT, regardless of the clinical stage. Most nonseminomas stained heavily for MT. The more advanced staged nonseminomas tended to stain more heavily for MT.

Conclusions: In view of the considerable experimental evidence as well as some inferential clinical data involving MT in cis-diamminedichloroplatin resistance, there appears to be a role for MT in cis-diamminedichloroplatin resistance in germ cell tumors. Further studies to elucidate the role of MT in germ cell tumor chemoresistance are warranted.

PubMed Disclaimer

LinkOut - more resources