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Comparative Study
. 1993 Aug 3;239(1-3):227-9.
doi: 10.1016/0014-2999(93)91000-d.

Comparative action of new highly potent bradykinin receptor antagonists in the guinea-pig trachea

A Trifilieff  1 , Y Amrani, Y Landry, J P Gies
Affiliations
Comparative Study

Comparative action of new highly potent bradykinin receptor antagonists in the guinea-pig trachea

A Trifilieff et al. Eur J Pharmacol. .

Abstract

We investigated the effect of two new bradykinin receptor antagonists, D-Arg0[Hyp3,D-HypE(trans-propyl)7,Oic8]bradykinin (NPC 17731) and D-Arg0[Hyp3,D-HypE(trans-thiophenyl)7,Oic8]bradykinin (NPC 17761) on [3H]bradykinin binding and on bradykinin-induced contraction of the guinea-pig trachea. Both of these compounds inhibited [3H]bradykinin binding with an affinity similar to that of unlabelled bradykinin. NPC 17731 inhibited bradykinin-induced contraction in a non-competitive manner, whereas NPC 17761 showed competitive antagonism. Therefore, NPC 17761 could contribute to the investigation of the bradykinin receptors in guinea-pig airways.

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