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. 1993 Dec;61(12):5394-7.
doi: 10.1128/iai.61.12.5394-5397.1993.

Antigenic switching of TSA 417, a trophozoite variable surface protein, following completion of the life cycle of Giardia lamblia

T C Meng  1 , M L Hetsko, F D Gillin
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Antigenic switching of TSA 417, a trophozoite variable surface protein, following completion of the life cycle of Giardia lamblia

T C Meng et al. Infect Immun. 1993 Dec.

Abstract

Expression of TSA 417, the predominant cysteine-rich variable surface protein of Giardia lamblia WB clone C6 trophozoites, did not change during encystation in vitro. However, in vitro excystation of cysts derived in vitro or in vivo consistently produced TSA 417 nonexpressing trophozoite populations, suggesting that completion of the life cycle leads to antigenic switching.

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