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. 1993 Dec;61(12):5401-5.
doi: 10.1128/iai.61.12.5401-5405.1993.

Hemin utilization is related to virulence of Streptococcus pneumoniae

S S Tai  1 , C J Lee, R E Winter
Affiliations

Hemin utilization is related to virulence of Streptococcus pneumoniae

S S Tai et al. Infect Immun. 1993 Dec.

Abstract

Streptococcus pneumoniae is a causative agent for bacterial pneumonia, otitis media, meningitis, and bacteremia. Mechanisms for acquisition of iron by this organism under low-iron conditions were investigated. Siderophore production was not detected by either chemical or biological methods. Its utilization of iron-containing compounds found in human hosts was tested. Both hemin and hemoglobin supported the full growth of S. pneumoniae in a culture lacking other iron sources, while lactoferrin and transferrin failed to do so. A mutant defective in hemin utilization was isolated and was less virulent than wild-type S. pneumoniae in experimental animals.

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References

    1. Infect Immun. 1983 Sep;41(3):1212-6 - PubMed
    1. J Bacteriol. 1954 Feb;67(2):220-32 - PubMed
    1. Infect Immun. 1984 Mar;43(3):1085-7 - PubMed
    1. J Bacteriol. 1984 Jul;159(1):271-7 - PubMed
    1. Infect Immun. 1984 Nov;46(2):585-9 - PubMed

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