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. 1976 Aug 11;21(2):113-8.
doi: 10.1007/BF02899148.

The fate of newly formed satellite cells during compensatory muscle hypertrophy

S Schiaffino, S P Bormioli, M Aloisi

The fate of newly formed satellite cells during compensatory muscle hypertrophy

S Schiaffino et al. Virchows Arch B Cell Pathol. .

Abstract

Compensatory hypertrophy was induced in the rat extensor digitorum longus muscle by extirpation of the synergistic tibialis anterior. Injections of 3H-thymidine (2 muCi/g body weight) was given at 24, 48, and 72 h after the operation. In animals killed immediately after the last injection both satellite cell nuclei and true muscle nuclei were labeled, whereas in animals killed 4 weeks later only true muscle nuclei were labeled. The results are interpreted as indicating incorporation of newly formed satellite cells into the fibers during compensatory hypertrophy.

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