Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Jul 21;124(2):91-9.
doi: 10.1007/BF00929200.

Signal transduction in Trypanosoma cruzi: opposite effects of adenylcyclase and phospholipase C systems in growth control

M M Oliveira  1 , E D Rocha, E Rondinelli, A V Arnholdt, J Scharfstein
Affiliations

Signal transduction in Trypanosoma cruzi: opposite effects of adenylcyclase and phospholipase C systems in growth control

M M Oliveira et al. Mol Cell Biochem. .

Abstract

Fetal calf serum (FCS), which is mitogenic for the pathogenic protozoa T. cruzi, inhibits cAMP production in basal and forskolin-stimulated epimastigotes. It also activates phosphoinositides hydrolysis yielding diacylglycerol and inositol phosphates (Ins-P). Ins-P production is enhanced by AlF4-, GTP or beta-gamma-methylene-GTP, thus implying G proteins mediation in the phenomenon. An enzyme with phospholipase C activity which may be involved in the phospholipid metabolism was partially characterized.

PubMed Disclaimer

References

    1. Biochem J. 1991 Apr 15;275 ( Pt 2):407-11 - PubMed
    1. Microbiol Rev. 1987 Dec;51(4):396-418 - PubMed
    1. J Clin Invest. 1979 Apr;63(4):580-7 - PubMed
    1. Science. 1975 Dec 12;190(4219):1110-2 - PubMed
    1. Mol Biochem Parasitol. 1989 Sep;36(2):101-8 - PubMed

Publication types

MeSH terms