Tobramycin in the treatment of severe and complicated urinary tract infections
- PMID: 823477
Tobramycin in the treatment of severe and complicated urinary tract infections
Abstract
Tobramycin is a new aminoglycoside antibiotic with pharmacological similarities to gentamicin. Eleven of 15 patients with a severe or complicated gram-negative urinary tract infection were cured by treatment with a five day course of tobramycin. No side effects were noted. This drug should prove beneficial for the treatment of severe gram-negative sepsis and promises to be particularly valuable for infections due to Pseudomonas aeruginosa and organisms resistant to gentamicin.
Similar articles
-
Sisomicin in the treatment of severe or complicated urinary tract infections.N Z Med J. 1978 Feb 8;87(605):91-4. N Z Med J. 1978. PMID: 273804
-
Clinical and laboratory study of tobramycin in the treatment of infections due to gram-negative organisms.Can Med Assoc J. 1977 Jul 23;117(2):138-43. Can Med Assoc J. 1977. PMID: 406032 Free PMC article.
-
[The use of tobramycin in severe infections (author's transl)].Sem Hop. 1978 Oct 18-25;54(33-36):1049-54. Sem Hop. 1978. PMID: 220716 French.
-
[Tobramycin--clinical pharmacology and chemotherapy].J Chemother. 1996 Jan;8 Suppl 1:3-30. J Chemother. 1996. PMID: 8948764 Review. Italian.
-
[Antibiotics combination cefradin-tobramycin for the treatment of severe infections in trauma surgery].Med Welt. 1979 Nov 9;30(45):1692-5. Med Welt. 1979. PMID: 393946 Review. German. No abstract available.
Cited by
-
Ototoxic destruction by co-administration of kanamycin and ethacrynic acid in rats.J Zhejiang Univ Sci B. 2011 Oct;12(10):853-61. doi: 10.1631/jzus.B1100040. J Zhejiang Univ Sci B. 2011. PMID: 21960349 Free PMC article.
-
Antibiotic treatment modulates Escherichia coli-derived bacterial extracellular vesicle (BEV) production and their capacity to upregulate ICAM-1 in human endothelial cells.bioRxiv [Preprint]. 2025 Jul 18:2025.05.12.653517. doi: 10.1101/2025.05.12.653517. bioRxiv. 2025. PMID: 40463015 Free PMC article. Preprint.