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Comparative Study
. 1976 Sep;6(5):602-6.
doi: 10.1007/BF01971577.

Anti-inflammatory drugs, prostaglandins and leucocyte migration

J R Walker, M J Smith, A W Ford-Hutchinson
Comparative Study

Anti-inflammatory drugs, prostaglandins and leucocyte migration

J R Walker et al. Agents Actions. 1976 Sep.

Abstract

The action of some non-steroidal acidic anti-inflammatory drugs, aspirin, phenylbutazone and indomethacin, in reducing leucocyte migration into the exudates of inert porous sponges implanted subdermally in the rat has been shown to be distinct from their effect in reducing the content of prostaglandins in the exudates. It is concluded that a component of the anti-inflammatory and antirheumatic actions of the drugs is concerned with a mechanism other than inhibition of prostaglandin biosynthesis.

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References

    1. Agents Actions. 1975 Oct;5(4):315-7 - PubMed
    1. Br J Pharmacol. 1972 Feb;44(2):330P - PubMed
    1. Br J Pharmacol. 1976 Jul;57(3):467P-468P - PubMed
    1. Nature. 1973 Nov 23;246(5430):215-7 - PubMed
    1. Nat New Biol. 1972 Jul 26;238(82):104-6 - PubMed

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