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. 1976 Aug;4(3):199-202.
doi: 10.1177/0310057X7600400305.

Effect of barbiturates on synaptic currents

T A Torda, P W Gage

Effect of barbiturates on synaptic currents

T A Torda et al. Anaesth Intensive Care. 1976 Aug.

Abstract

Thiopentone and pentobarbitone reduce the time constant of decay of miniature end-plate currents when applied in anaesthetic concentrations to the neuromuscular junction. Such an effect at central synapses would lead to failure of synaptic transmission in the central nervous system and may reflect a common mode of action of many anaesthetic drugs.

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