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Case Reports
. 1993 Sep;37(9):1962-5.
doi: 10.1128/AAC.37.9.1962.

Fluconazole resistance in Candida glabrata

C A Hitchcock  1 , G W Pye, P F Troke, E M Johnson, D W Warnock
Affiliations
Case Reports

Fluconazole resistance in Candida glabrata

C A Hitchcock et al. Antimicrob Agents Chemother. 1993 Sep.

Abstract

We report a case of infection with Candida glabrata in which the organism became resistant to fluconazole and in which pre- and posttreatment isolates were available for comparison. The organism was cross-resistant to ketoconazole and itraconazole, in common with other azole-resistant yeasts. Fluconazole was a potent inhibitor of cytochrome P-450-dependent 14 alpha-sterol demethylase (P-450DM) in lysates of cells from both susceptible and resistant cultures (50% inhibitory concentration, 0.2 microM), indicating that resistance was unrelated to changes in P-450DM. Instead, it appeared to arise from a permeability barrier to fluconazole, since resistant cells were unable to take up radiolabelled drug.

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