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. 1993 Nov;67(5):227-30.
doi: 10.1007/BF01715052.

Idarubicin is active on MDR cells: evaluation of DNA synthesis inhibition on P388 cell lines

M Petrini  1 , L Mattii, P Valentini, A R Sabbatini, B Grassi, M Grandi
Affiliations

Idarubicin is active on MDR cells: evaluation of DNA synthesis inhibition on P388 cell lines

M Petrini et al. Ann Hematol. 1993 Nov.

Abstract

Multidrug resistance is frequently found in patients affected by hematological malignancies and has been related to a poor prognosis of acute leukemia. In the present paper we report results concerning the activity of idarubicin, an anthracycline derivative, on the leukemic P388 and P388 doxorubicin-resistant cell lines. The results clearly show that idarubicin inhibits DNA synthesis in the resistant cell line more actively than doxorubicin.

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