Serologic examination of the Westphal-type lipopolysaccharides of Pasteurella multocida

Abstract

The serologic specificities of the Westphal-type lipopolysaccharides from 16 serotypes of Pasteurella multocida were compared with those reported for the heat-stable typing antigens in the gel diffusion precipitin test. Like the heat-stable typing antigen, the Westphal-type lipopolysaccharide from each of the serotypes reacted only with its homologous antiserum in 14 of the 16 serotypes. The lipopolysaccharide from type strains representing serotypes 2 and 5 reacted with either of the corresponding typing sera, as did field isolates of these serotypes to a lesser extent. Although differences among the properties of these antigens were minor, the lipopolysaccharide appeared to be a major component of the heat-stable antigen responsible for the type specificity.