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. 1976 Oct;29(10):916-22.
doi: 10.1136/jcp.29.10.916.

Cytology of myeloma cells

F G Hayhoe, Z Neuman

Cytology of myeloma cells

F G Hayhoe et al. J Clin Pathol. 1976 Oct.

Abstract

A cytological, cytochemical, and cytometric study of plasma cells from 195 cases of multiple myeloma showed that, contrary to earlier reports, flaming cells, thesaurocytes, and intranuclear inclusions are not confined to IgA-secreting cases but are common also in IgG and Bence Jones varieties of myeloma. IgA-secreting cells are not larger, nor do they have a lower nuclear cytoplasmic ratio than other myeloma cells. On average, for a given mass of tumour, Bence-Jones, IgG, and IgA varieties of myeloma produce amounts of paraprotein in the ratio 1 to 1-6 to 2-7.

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