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. 1993 Jul-Aug;39(4):47-52.

[Oxygen-dependent processes in the liver and immunologic reactivity of rats in chronic liver damage induced by carbon tetrachloride]

[Article in Russian]
I N Alekseeva, T M Bryzgina, S I Pavlovich, V I Nosar, L I Aleksiuk, N V Makogon, Ia N Gotsuliak, T V Martynova, O V Sidorenko, V S Sukhina
  • PMID: 8243715

[Oxygen-dependent processes in the liver and immunologic reactivity of rats in chronic liver damage induced by carbon tetrachloride]

[Article in Russian]
I N Alekseeva et al. Fiziol Zh (1978). 1993 Jul-Aug.

Abstract

The chronic hepatitis in Wistar rats was induced by seven subcutaneous injections of carbon tetrachloride (0.3 ml of 50% oil solution per 1 kg of body mass) made each third day. It was shown that cytochromes P-450 and b5 content, demethylase activity in the liver microsomal fraction as well as the oxygen tension in the liver tissue were decreased, while lipid peroxidation was intensified. The PHA-induced blood lymphocyte blastogenesis was inhibited and concentration of circulating immune complexes in the blood was higher than that in intact animals.

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