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. 1976 Sep;57(3):603-5.
doi: 10.1093/jnci/57.3.603.

Preferential cytotoxicity of 5-thio-D-glucose against hypoxic tumor cells

C W Song, J J Clement, S H Levitt

Preferential cytotoxicity of 5-thio-D-glucose against hypoxic tumor cells

C W Song et al. J Natl Cancer Inst. 1976 Sep.

Abstract

5-Thio-D-glucose effectively killed hypoxic mastocytoma cells of DBA/2J mice, whereas it merely suppressed the growth of oxic cells. This specific toxicity suggested that 5-thio-D-glucose may be a useful adjuvant to radiotherapy by eliminating hypoxic protection.

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