doi: 10.7164/antibiotics.46.1605.
Inactivated products of rifampicin by pathogenic Nocardia spp.: structures of glycosylated and phosphorylated metabolites of rifampicin and 3-formylrifamycin SV
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- PMID: 8244890
- DOI: 10.7164/antibiotics.46.1605
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Inactivated products of rifampicin by pathogenic Nocardia spp.: structures of glycosylated and phosphorylated metabolites of rifampicin and 3-formylrifamycin SV
J Antibiot (Tokyo).
1993 Oct.
Free article
Abstract
Rifampicin (1) was converted into four inactivated products by pathogenic Nocardia, RIP-1 and RIP-2 by N. brasiliensis and RIP-3 and RIP-4 by N. otitidiscaviarum. MS and NMR analysis showed the compounds to be 3-formyl-23-[O-(beta-D-glucopyranosyl)]rifamycin SV (2), 23-[O-(beta-D-glucopyranosyl)]rifampicin (3), 21-(O-phosphoryl)rifampicin (4) and 3-formyl-21-(O-phosphoryl)-rifamycin SV (5), respectively.
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