Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Dec;53(6):1250-5.

Localization of the Krabbe disease gene (GALC) on chromosome 14 by multipoint linkage analysis

R Oehlmann  1 , J Zlotogora, D A Wenger, R G Knowlton
Affiliations

Localization of the Krabbe disease gene (GALC) on chromosome 14 by multipoint linkage analysis

R Oehlmann et al. Am J Hum Genet. 1993 Dec.

Abstract

The gene responsible for Krabbe disease, an autosomal recessive disorder caused by deficiency of galactocerebrosidase (GALC), was localized by multipoint linkage analysis on chromosome 14. Eight mapped dinucleotide repeat polymorphisms were tested for linkage to GALC. Two-point linkage analysis demonstrated close linkage of GALC and D14S48, with Z = 13.69 at theta = 0. Multipoint analysis yielded strong support for this finding, with maximum likelihood for GALC located within 1 cM of D14S48. This analysis also identified markers that clearly flank the GALC locus, as the map order of D14S53-GALC-D14S45 is favored by odds greater than 10(6):1. Additional support for close linkage of GALC and D14S48 comes from the apparent linkage disequilibrium between these two loci in a consanguineous Druze community in Israel. These data localize GALC to 14q24.3-q32.1.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443-6 - PubMed
    1. Am J Med Genet. 1985 Aug;21(4):765-70 - PubMed
    1. Am J Hum Genet. 1989 Feb;44(2):198-207 - PubMed
    1. Genomics. 1992 Jul;13(3):532-6 - PubMed
    1. Am J Hum Genet. 1990 Jul;47(1):37-44 - PubMed

Publication types