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Review
. 1993 Oct;7(5):630-4.
doi: 10.1007/BF00852570.

Regulation of Na+,K(+)-ATPase gene expression: a model to study terminal differentiation

G Celsi  1 , Z M Wang
Affiliations
Review

Regulation of Na+,K(+)-ATPase gene expression: a model to study terminal differentiation

G Celsi et al. Pediatr Nephrol. 1993 Oct.

Abstract

This review focuses on the ontogeny of factors involved in the transcriptional regulation of Na+,K(+)-ATPase expression. The Na+,K(+)-ATPase enzyme is of vital importance for cell function. It is likely that the limited availability of Na+,K(+)-ATPase in infant tissue is the major limiting factor for adaptation to extra-uterine life in several organs. The factors regulating Na+,K(+)-ATPase gene transcription in infancy are discussed. Special emphasis is given to the role of circulating hormones such as glucocorticoids and thyroxine.

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