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Case Reports
. 1993 Sep;18(5):441-4.
doi: 10.1111/j.1365-2230.1993.tb02246.x.

Malignant atrophic papulosis. A report of two cases with altered fibrinolysis and platelet function

F J Vázquez-Doval  1 , F Ruiz de Erenchun, J A Páramo, E Quintanilla
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Free article
Case Reports

Malignant atrophic papulosis. A report of two cases with altered fibrinolysis and platelet function

F J Vázquez-Doval et al. Clin Exp Dermatol. 1993 Sep.
Free article

Abstract

Malignant atrophic papulosis is a systemic vaso-occlusive disorder characterized by typical skin lesions. We report two new cases with impairment of blood fibrinolytic activity and alterations in platelet function. The first case showed an increase in plasminogen activator inhibitor-1 (PAI-1) activity, and the second case had a decrease in platelet aggregation induced by adenosine diphosphate and adrenaline but normal with collagen. The impairment of blood fibrinolytic activity and platelet aggregation may have pathogenic and therapeutic implications in malignant atrophic papulosis.

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