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. 1993 Sep 28;242(2):205-8.
doi: 10.1016/0014-2999(93)90082-s.

SCH 23390 decreases self-stimulation of the medial prefrontal cortex in the rat

R Sabater  1 , J A Saez, J M Ferrer
Affiliations

SCH 23390 decreases self-stimulation of the medial prefrontal cortex in the rat

R Sabater et al. Eur J Pharmacol. .

Abstract

We studied the effects of peripheral and central administration of SCH 23390, a selective antagonist of dopamine D1 receptors, on intracranial self-stimulation of the medial prefrontal cortex of the rat. Intraperitoneal injections of SCH 23390 produced a dose-related decrease in self-stimulation. Unilateral microinjections of SCH 23390 into the medial prefrontal cortex also produced a dose-related decrease in self-stimulation in the ipsilateral medial prefrontal cortex. However, self-stimulation of the contralateral, noninjected prefrontal cortex, used as control, was not affected. Together with previous data, the present results suggest that the dopamine neurotransmission involved in self-stimulation of the prefrontal cortex of the rat is mediated by dopamine D1 receptors.

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