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Comparative Study
. 1993 Oct;31(10):2679-82.
doi: 10.1128/jcm.31.10.2679-2682.1993.

Quantitative evaluation of hepatitis C virus RNA in patients with concurrent human immunodeficiency virus infections

K E Sherman  1 , J O'Brien, A G Gutierrez, S Harrison, M Urdea, P Neuwald, J Wilber
Affiliations
Comparative Study

Quantitative evaluation of hepatitis C virus RNA in patients with concurrent human immunodeficiency virus infections

K E Sherman et al. J Clin Microbiol. 1993 Oct.

Abstract

Quantitation of the hepatitis C virus (HCV) provides a powerful epidemiologic and therapeutic method for the evaluation of infected patients. In this study semiquantitative reverse transcriptase polymerase chain reaction (PCR) is compared with a new branched DNA signal amplification methodology. Samples from HCV-infected patients as well as from human immunodeficiency virus-infected patients were evaluated. Reverse transcriptase PCR correlated well with the branched DNA assay (r = 0.7036, P < 0.05). HCV RNA was found to occur at significantly higher titers (P < 0.05) in patients coinfected with the human immunodeficiency virus compared with titers in those infected with HCV alone. Immune status as defined by the CD4+ count was not associated with the observed difference in viral titer.

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