Antigenic characterization of a new gibbon ape leukemia virus isolate: seroepidemiologic assessment of an outbreak of gibbon leukemia

Abstract

A type-C virus recently isolated from a leukemic gibbon in a colony located on Hall's Island, Bermuda, was characterized with respect to the antigenic properties of its gag and env gene-coded proteins. This virus, designated GaLV-H, was found to be closely related immunologically to type-C viruses previously isolated from gibbons (GaLV-SF, GaLV-SEATO, GaLV-Br) and from woolly monkey (SSAV). However, GaLV-H was readily differentiated from these isolates in a radioimmunoassay for its env gene product, gp70. Seroepidemiology established that GaLV-H was horizontally transmitted among gibbons within the colony. There was no evidence of exposure leading to an immune response to the virus or viral antigenemia in humans working in association with these animals.