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Comparative Study
. 1994 Jan;68(1):526-9.
doi: 10.1128/JVI.68.1.526-529.1994.

Investigation of the specificity of the herpes simplex virus type 1 protease by point mutagenesis of the autoproteolysis sites

P J McCann 3rd  1 , D R O'Boyle 2nd, I C Deckman
Affiliations
Comparative Study

Investigation of the specificity of the herpes simplex virus type 1 protease by point mutagenesis of the autoproteolysis sites

P J McCann 3rd et al. J Virol. 1994 Jan.

Abstract

The herpes simplex virus type 1 (HSV-1) protease is cleaved at two autoprocessing sites during viral maturation, one of which shares amino acid identity with its substrate, ICP35. Similar autoprocessing sites have been observed within other members of the Herpesviridae. Introduction of point mutations within the autoprocessing sites of the HSV-1 protease indicated that specificity resides within the P4-P1' region of the cleavage sites.

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References

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