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Comparative Study
. 1994 Jan;68(1):63-8.
doi: 10.1128/JVI.68.1.63-68.1994.

Sequence conservation in field and experimental isolates of Borna disease virus

P A Schneider  1 , T Briese, W Zimmermann, H Ludwig, W I Lipkin
Affiliations
Comparative Study

Sequence conservation in field and experimental isolates of Borna disease virus

P A Schneider et al. J Virol. 1994 Jan.

Abstract

Coding and noncoding sequences were analyzed from field and experimental isolates of Borna disease virus. For a 24-kDa protein, maximum divergence was 1.5% at the predicted amino acid level and 3.1% at the nucleotide level. For a 40-kDa protein, maximum divergence was 1.1% at the predicted amino acid level and 4.1% at the nucleotide level. The highest variability in sequence (10%) was found in a 40-nucleotide stretch of genomic RNA between coding sequences for the 40- and 24-kDa proteins. The degree of sequence conservation in these isolates, passaged in various host species in vivo and in vitro over a period of 64 years, is unusual for negative-strand RNA viruses.

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References

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