Nicotinamide and carbogen: major effect on the radiosensitivity of EMT6 and HRT18 tumours
- PMID: 8255997
- DOI: 10.1016/0167-8140(93)90059-h
Nicotinamide and carbogen: major effect on the radiosensitivity of EMT6 and HRT18 tumours
Abstract
The effect of nicotinamide and/or carbogen breathing on the response of EMT6 and HRT18 tumours, irradiated in vivo, was evaluated using an in vitro colony assay. In the single dose schedules, the most efficient treatment was carbogen plus nicotinamide compared to air breathing mice. In a fractionated regime carbogen plus nicotinamide increased also response to radiation.
Similar articles
-
Nicotinamide and carbogen: relationship between pO2 and radiosensitivity in three tumour lines.Int J Radiat Biol. 1994 Mar;65(3):379-86. doi: 10.1080/09553009414550441. Int J Radiat Biol. 1994. PMID: 7908317
-
Nicotinamide, Fluosol DA and Carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo.Br J Cancer. 1991 Jan;63(1):109-13. doi: 10.1038/bjc.1991.22. Br J Cancer. 1991. PMID: 1846549 Free PMC article.
-
Carbogen and nicotinamide as radiosensitizers in a murine mammary carcinoma using conventional and accelerated radiotherapy.Int J Radiat Oncol Biol Phys. 1996 Jan 15;34(2):357-65. doi: 10.1016/0360-3016(95)02087-x. Int J Radiat Oncol Biol Phys. 1996. PMID: 8567336
-
A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments.Radiother Oncol. 1991 Oct;22(2):81-91. doi: 10.1016/0167-8140(91)90002-x. Radiother Oncol. 1991. PMID: 1835542 Review.
-
Modulation of tumor oxygenation and radiosensitivity by a perfluorooctylbromide emulsion.Radiother Oncol. 1991 Oct;22(2):92-8. doi: 10.1016/0167-8140(91)90003-y. Radiother Oncol. 1991. PMID: 1957007 Review.
Cited by
-
The effects of carbogen and nicotinamide on intravascular oxyhaemoglobin saturations in SCCVII and KHT murine tumours.Br J Cancer. 1995 May;71(5):945-9. doi: 10.1038/bjc.1995.183. Br J Cancer. 1995. PMID: 7734318 Free PMC article.
-
Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients.Br J Cancer. 1995 Jul;72(1):198-205. doi: 10.1038/bjc.1995.303. Br J Cancer. 1995. PMID: 7599052 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources