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. 1976 Nov 2;144(5):1188-203.
doi: 10.1084/jem.144.5.1188.

The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor

A E Postlethwaite, R Snyderman, A H Kang

The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor

A E Postlethwaite et al. J Exp Med. .

Abstract

A quantitative assay that measures fibroblast chemotaxis in vitro is described. Application of this technique has revealed that peripheral blood lymphocytes stimulated by antigen or mitogen in vitro produce a factor that is chemotactic for human dermal fibroblasts. This lymphocyte-derived chemotactic factor for fibroblasts (LDCF-F) is different from the lymphokine that is chemotactic for monocytes or macrophages. Macrophages are required for the generation of LDCF-F by T lymphocytes stimulated by phytohemagglutinin. The fibroblast chemotactic factor is heat stable (56 degrees C for 30 min), trypsin sensitive, and neuraminidase resistant. LDCF-F could function to attact connective tissue fibroblasts to sites at which cell-mediated immune reactions are occurring in vivo.

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