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. 1993 Jun;10(3):214-8.
doi: 10.1007/BF00702202.

A model for cleavage of O-glycosidic bonds in glycoproteins

F M Ibatullin  1 , A M Golubev, L M Firsov, K N Neustroev
Affiliations

A model for cleavage of O-glycosidic bonds in glycoproteins

F M Ibatullin et al. Glycoconj J. 1993 Jun.

Abstract

The present work investigated the possibility of cleavage of alpha-linkages between mannose or galactose and serine/threonine residues by alpha-mannosidase and alpha-galactosidase. The study was carried out initially with model synthetic compounds imitating the O-glycosidic bond in glycoproteins, and further with glucoamylase. It was shown that alpha-mannosidase and alpha-galactosidase can hydrolyse these linkages after proteolytic digestion of glucoamylase.

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