Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Sep 30;4(12):1353-5.
doi: 10.1097/00001756-199309150-00017.

Middle ear procaine injection before surgical labyrinthectomy reduces nystagmus

C L Darlington  1 , P F Smith
Affiliations

Middle ear procaine injection before surgical labyrinthectomy reduces nystagmus

C L Darlington et al. Neuroreport. .

Abstract

A middle ear injection of 2% procaine (0.1 ml) was given to guinea-pigs 15-30 min before a surgical unilateral labyrinthectomy (UL) and the effects on spontaneous ocular nystagmus (SN) were observed. The pre-UL injection of procaine significantly reduced SN frequency compared to vehicle-injected controls or to animals receiving a post-UL injection of procaine. This result supports the hypothesis that the decrease in resting activity observed in vestibular nucleus neurones following UL may be due, at least in part, to Ca2+ influx due to injury-related glutamate release from vestibular nerve terminals.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources