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. 1993 Oct;44(2-3):319-28.
doi: 10.1016/0166-0934(93)90066-z.

Detection of a shared idiotope on two encephalomyocarditis virus neutralizing monoclonal antibodies by neutralization inhibition enzyme immunoassay

C A Kraaijeveld  1 , T A Oosterlaken, F Vlaspolder, P W van Dijk, M Harmsen, I M Fernández, B J Benaissa-Trouw, H Snippe
Affiliations

Detection of a shared idiotope on two encephalomyocarditis virus neutralizing monoclonal antibodies by neutralization inhibition enzyme immunoassay

C A Kraaijeveld et al. J Virol Methods. 1993 Oct.

Abstract

Idiotypic cross-reactivity between encephalomyocarditis virus (EMCV) neutralizing monoclonal antibodies UM 21.1 (IgG2b) and UM 21.3 (IgG2a) was detected by neutralization inhibition enzyme immunoassay using polyclonal and monoclonal anti-idiotypic antibodies. One strongly cross-reactive anti-idiotypic monoclonal antibody, designated 21.1A5 (IgG2b), might recognize a recurrent idiotope on EMCV neutralizing antibodies but it did not induce EMCV neutralizing anti-anti-idiotypic antibodies in homologous BALB/c mice.

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