Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Dec 15;90(24):11960-4.
doi: 10.1073/pnas.90.24.11960.

Transcriptional regulatory elements downstream of the JunB gene

E D Perez-Albuerne  1 , G Schatteman, L K Sanders, D Nathans
Affiliations

Transcriptional regulatory elements downstream of the JunB gene

E D Perez-Albuerne et al. Proc Natl Acad Sci U S A. .

Abstract

JunB is an immediate early transcription factor that is induced by a variety of extracellular signaling agents, including growth factors, phorbol esters, and agents that elevate cyclic AMP. The mechanism of activation of the gene encoding JunB by these agents is not well understood. By using the JunB gene together with flanking DNA in transfection experiments, we show that a serum response element (SRE) and/or a cAMP response element (CRE) downstream of the gene mediate the response of the gene in mouse NIH 3T3 cells to serum, platelet-derived growth factor, basic fibroblast growth factor, phorbol ester, and forskolin. In addition, a segment of DNA just upstream of the TATA box is required for optimal activation of the gene.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nucleic Acids Res. 1987 Jul 10;15(13):5490 - PubMed
    1. J Biol Chem. 1993 Jul 5;268(19):14482-9 - PubMed
    1. Methods Enzymol. 1987;154:329-50 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1487-91 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7795-9 - PubMed

Publication types

MeSH terms

Associated data