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. 1993 Dec 17;262(5141):1874-7.
doi: 10.1126/science.8266076.

Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4

M Kondo  1 , T Takeshita, N Ishii, M Nakamura, S Watanabe, K Arai, K Sugamura
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Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4

M Kondo et al. Science. .

Abstract

The gamma chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding and intracellular signal transduction. A monoclonal antibody to the gamma chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line. Another monoclonal antibody, TUGm3, which reacted with the gamma chain cross-linked with IL-2, also immunoprecipitated the gamma chain when cross-linked with IL-4. These results suggest that the IL-2 receptor gamma chain is functionally involved in the IL-4 receptor complex.

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Comment in

  • 'Bubble boy' paradox resolved.
    Nowak R. Nowak R. Science. 1993 Dec 17;262(5141):1818. doi: 10.1126/science.8266068. Science. 1993. PMID: 8266068 No abstract available.

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