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. 1993 Dec 17;262(5141):1889-92.
doi: 10.1126/science.8266081.

Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc

A Shrivastava  1 , S Saleque, G V Kalpana, S Artandi, S P Goff, K Calame
Affiliations

Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc

A Shrivastava et al. Science. .

Abstract

Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. The yeast two-hybrid system was used to screen a human complementary DNA (cDNA) library for proteins that associate with YY1, and a c-myc cDNA was isolated. Affinity chromatography confirmed that YY1 associates with c-Myc but not with Max. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1.

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