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Clinical Trial
. 1993 Sep-Oct;13(5C):1839-40.

Adjuvant portal liver infusion with 5-fluorouracil and mitomycin in colorectal cancer. SAKK

W Weber  1 , U Laffer, U Metzger
Affiliations
  • PMID: 8267390
Clinical Trial

Adjuvant portal liver infusion with 5-fluorouracil and mitomycin in colorectal cancer. SAKK

W Weber et al. Anticancer Res. 1993 Sep-Oct.

Abstract

Between 1981 and 1987, 533 patients from 9 institutions were entered in a randomized trial to assess the value of adjuvant perioperative portal infusion with Fluorouracil and Mitomycin as compared to radical surgery alone. Analysis of 469 evaluable patients at a median follow-up of 5.8 years revealed 110 recurrences in the control and 94 recurrences in the infusion group. Estimated 5-year disease-free survival was 52% and 61% respectively (hazard ratio: 1:0.75; 95% confidence interval 0.57-0.99; p = 0.046). Overall survival was 59% in the control and 69% in the infusion group (p = 0.048). Adjuvant portal infusion did not influence the occurrence of liver metastases but reduced the overall recurrence rate.

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