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. 1993 Oct;43(10):1052-5.

Synthesis of some 1,4,5,6,7,8-hexahydroquinoline derivatives and their calcium antagonistic activity

C Safak  1 , I Erdemli, R Sunal
Affiliations
  • PMID: 8267668

Synthesis of some 1,4,5,6,7,8-hexahydroquinoline derivatives and their calcium antagonistic activity

C Safak et al. Arzneimittelforschung. 1993 Oct.

Abstract

Twenty-seven new 2-methyl-3-acetyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives have been prepared. Their structures were confirmed by UV, IR, 1H-NMR and elementary analysis. The calcium antagonistic activity of these compounds was tested in K(+)-depolarized taenia coli precontracted with 1 mmol/l Ca+2.

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