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Comparative Study
. 1993 Dec 14;1216(3):469-74.
doi: 10.1016/0167-4781(93)90016-7.

Genomic sequence of mouse COL1A1 encoding the collagen propeptides

S P Fenton  1 , S R Lamande, M Hannagan, A Stacey, R Jaenisch, J F Bateman
Affiliations
Comparative Study

Genomic sequence of mouse COL1A1 encoding the collagen propeptides

S P Fenton et al. Biochim Biophys Acta. .

Abstract

The nucleotide sequences of the mouse pro alpha 1(I) gene regions coding for the N- and C-propeptides is reported. The exon-intron structure was highly homologous to human COL1A1 and the deduced amino acid sequences of the N- and C-propeptides showed 67% and 91% identity with the human sequence. This gene sequence information will allow the production of specific gene mutations by site-directed mutagenesis to study the structure and function of these important propeptide domains.

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